Web3 Aug 2024 · Fpk1 controls TORC2-dependent actin polarization and endocytosis via distinct effectors Previously, we had observed that codeletion of FPK1 and FPK2 modestly suppresses the toxicity and largely prevents the actin depolarization and endocytosis arrest otherwise observed upon TORC2 inhibition with NVP-BHS345 in TOR1MT cells ( 15. ). Web5 Jan 2024 · kinase, Fpk1, a known flippase activator. We show that Ypk1 phos-phorylates and thereby down-regulates Fpk1, and further that a complex sphingolipid counteracts …
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Systematic functional analysis of kinases in the fungal pathogen
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