Ctcf zinc finger folding cristallography
Web5.1 CTCF genome organizer and the cohesin complex. CTCF (CCCTC-binding factor) is a multiple zinc finger protein that exerts diversified functions under different genomic … Transcriptional repressor CTCF also known as 11-zinc finger protein or CCCTC-binding factor is a transcription factor that in humans is encoded by the CTCF gene. CTCF is involved in many cellular processes, including transcriptional regulation, insulator activity, V(D)J recombination and regulation of … See more CCCTC-Binding factor or CTCF was initially discovered as a negative regulator of the chicken c-myc gene. This protein was found to be binding to three regularly spaced repeats of the core sequence CCCTC and thus … See more The primary role of CTCF is thought to be in regulating the 3D structure of chromatin. CTCF binds together strands of DNA, thus forming chromatin loops, and anchors DNA to cellular structures like the nuclear lamina. It also defines the boundaries between active and … See more CTCF binds to itself to form homodimers. CTCF has also been shown to interact with Y box binding protein 1. CTCF also co-localizes with cohesin, which extrudes chromatin loops by actively translocating one or two DNA strands through its ring-shaped structure, … See more • CCCTC-binding+factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH) • FactorBook CTCF See more The binding of CTCF has been shown to have many effects, which are enumerated below. In each case, it is unknown if CTCF directly evokes the outcome or if it does so indirectly (in … See more CTCF binds to the consensus sequence CCGCGNGGNGGCAG (in IUPAC notation). This sequence is defined by 11 zinc finger motifs in its structure. CTCF's binding is disrupted by CpG methylation of the DNA it binds to. On the other hand, CTCF binding may … See more • Ohlsson R, Renkawitz R, Lobanenkov V (2001). "CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease". Trends Genet. 17 (9): 520–7. doi:10.1016/S0168-9525(01)02366-6. PMID 11525835. • Klenova EM, Morse … See more
Ctcf zinc finger folding cristallography
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WebFeb 16, 2024 · Silencing CTCF or COL1A1/COL1A3 markedly inhibited cell growth and migration in the metastatic GC cell line BGC823. Collectively, this ECM-related 7-gene signature provides a novel insight for survival prediction among GC patients. The zinc finger protein CTCF regulates ECM-related genes, thereby promoting GC cell growth … WebCTCF is a multivalent transcription factor and uses different combinations of zinc fingers (ZFs) to bind diverse target sequences . Tumor-derived point mutations in ZF3 and ZF7 …
WebApr 1, 2024 · CTCF and CTCFL contain N-terminal and C-terminal domains and a central 11-zinc finger region. CTCF binds to approximately 80 000 sites on mammalian chromosomes [33, 34] through a subset of its eleven zinc fingers (ZFs).The ZFs of CTCFL and CTCF have significant homology with the ZFs of CTCF (74.1%), but the N-terminal … WebAug 31, 2024 · CCCTC-binding factor (CTCF) is a zinc-finger protein, serving an important part in the genome architecture as well as some biochemical processes. Over 70,000 …
WebJun 5, 2015 · CCCTC-binding factor (CTCF) is a highly conserved zinc finger protein and is best known as a transcription factor. It can function as a transcriptional activator, a repressor or an insulator ... WebSep 13, 2024 · An exceptionally conserved transcriptional repressor, CTCF, employs different combinations of zinc fingers to bind diverged promoter sequences of avian and mammalian c-myc oncogenes. Mol. Cell ...
WebCTCF is an evolutionarily conserved zinc finger (ZF) phosphoprotein that binds through combinatorial use of its 11 ZFs to ∼50 bp target sites that have remarkable sequence variation. Formation of different CTCF–DNA complexes, some of which are methylation-sensitive, results in distinct functions, including gene activation, repression, silencing and …
WebSep 8, 2024 · CTCF is an 11-zinc-finger DNA-binding protein that acts as a transcriptional repressor and insulator as well as an architectural protein required for 3D genome … greenlife cookware ptfe griddlegreen life cookware pinkWebCTCF (CCCTC-binding factor) is a multiple zinc finger protein that exerts diversified functions under different genomic contexts. CTCF was first isolated and cloned on the basis of its ability to bind to highly divergent 50–60 bp sequences within the promoter region of the chicken Myc gene [153] . flying apron redmondWebThe CTCF zinc finger domain is required for recruitment to DSB Numerousproteinsinvolved inthe DNA repairprocessare PARylated (23), and this posttranslational modifi cation can play a significant role in the recruitment of proteins to DNA breakages ( 9, 29). We observe that the association of CTCF with PARylation is substantially enriched flying apronsWebMar 6, 2024 · However, the role of CTCF in DNA damage response remains elusive. Here, we show that CTCF is quickly recruited to the sites of DNA damage. The fast recruitment is mediated by the zinc finger domain and poly (ADP-ribose) (PAR). Further analyses show that only three zinc finger motifs are essential for PAR recognition. green life cookware red flatWebFeb 16, 2024 · Silencing CTCF or COL1A1/COL1A3 markedly inhibited cell growth and migration in the metastatic GC cell line BGC823. Collectively, this ECM-related 7-gene … green life cookware phone numberWeb5.1 CTCF genome organizer and the cohesin complex. CTCF (CCCTC-binding factor) is a multiple zinc finger protein that exerts diversified functions under different genomic contexts. CTCF was first isolated and cloned on the basis of its ability to bind to highly divergent 50–60 bp sequences within the promoter region of the chicken Myc gene ... green life cookware reviews